Micky van de Ven Double Ends The Toffees' Run at New Home Ground
Micky van de Ven became the first backline player to net two goals in a Premier League match for Spurs since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven heads home two times in opening period
Everton's Jake O'Brien has equalizer ruled after VAR review
Senegalese midfielder nets final goal in dying moments
The defeat is Everton's first at their new ground
Micky van de Ven scored twice as Tottenham prolonged their unbeaten run in away games in the top division and delivered the Toffees their initial loss at their new home.
Everton were undefeated in their last five matches at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after more than a century at the end of the previous campaign.
But Tottenham's leader Van de Ven struck twice from corners in the first half to place their impressive record at risk, and they were unable to turn it around before the midfielder - set up by former Toffees attacker the Brazilian - headed home a third to seal the victory.
Jake O'Brien believed he had equalized the scores five minutes after Van de Ven's first goal, glancing a powerful header past the Spurs keeper from an set-piece.
Beto, meanwhile, missed a number of opportunities, while Vicario made a succession of fine saves to ensure Tottenham went five matches on the road without defeat in the English top flight.
But the video assistant referee stepped in, instructing the match official to check the goal on the pitchside monitor and the official decided that the winger and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
The win moves the manager's side up to third in the Premier League, a handful of points off local foes and table-toppers the Gunners.
Everton stay in 14th position and are half a dozen points ahead of the drop zone.
Tottenham analysis: Van de Ven excels in role at both ends of pitch
After a uninspiring midweek performance in the Champions League against Monaco, where they managed a mere attempts on target, the manager chose the French striker in attack instead of former Toffees player Richarlison.
The summer signing was failed to influence the game before being replaced for Richarlison after an hour on the pitch, but it turns out he proved unnecessary in the final outcome.
Defender the Dutchman converted into an offensive threat to be reckoned with.
Tottenham's opening strike came from a well-worked set-piece play, with the midfielder heading the ball back across the face of goal for an free the defender to head home.
And the captain - filling in as captain in Cristian Romero's unavailability - notched his second in added time as he rose above Jordan Pickford to nod in.
Van de Ven was just as outstanding in defence, combining well with Kevin Danso as the duo dealt excellently with the numerous deliveries sent their way by Everton.
Everton analysis: Everton lacking striker's instinct
Everton's recent stadium had been a happy hunting ground, but it appears the freshness may have faded slightly and fans headed to the exits after Sarr's final goal for Spurs.
The break in Everton's winning streak at home won't be a massive worry for the manager, but their striker situation will be.
The forward and the other striker - the Everton's pair of established centre-forwards - had netted just one league goal combined before Sunday's outing.
And they were unable to contribute to that poor tally on a damp and dreary night on in Liverpool.
The striker's performance was epitomized when he chose to overhead kick a clear chance from close range, despite having space and time to readjust for a simpler attempt that would have challenged Vicario.
The substitute, too, failed to influence the game after coming on for the starter in the 65th minute.
It wasn't for a shortage of chance. The majority of Everton's attacks came through Grealish and Ndiaye, who relentlessly delivered threatening crosses into the Spurs box.
Upcoming fixtures for both teams?
Everton: The team head to the Stadium of Light in the top flight on Monday, 3 November at 8 PM.
Spurs: Spurs travel to St James' Park on Wednesday, 29 October for their next round Carabao Cup match against the Magpies.