British Air Force Typhoon FGR4s have operated alongside French aircraft in a coordinated attack on an hidden munitions depot in Syrian territory operated by the IS group, according to the British defence ministry.
The location, identified by surveillance, was assessed as housing weapons and explosive materials, the announcement noted, and was located in mountains just north of the historic site of Palmyra in Syria's central region.
"Our fighter planes utilized laser-guided Paveway IV weapons to target a number of approach shafts down to the facility... initial indications suggest the objective was successfully hit," the ministry announced.
There was no sign of any civilian impact in the operation late on Saturday and each participating jet made a safe return, the ministry further stated.
The British jets were backed up by a Voyager tanker plane.
The Islamic State group - alternatively referred to as ISIS - imposed extremist governance over large swathes of Syria and Iraq until 2019.
"This strike demonstrates British leadership, and commitment to stand shoulder to shoulder with allied nations, to stamp out any revival of IS and their harmful and extremist ideologies in the area," UK Defence Secretary the minister remarked.
British military aircraft have conducted patrols over Syrian airspace to "deter any attempted comeback" of IS following its military defeat at the Baghuz confrontation in the year 2019, the MoD reported.
"I want to thank the personnel of British forces participating in this strike for their professionalism and their courage," he added. "They were part of thousands of British personnel stationed over Christmas and New Year. This mission, to remove militants who endanger our way of life, shows how UK forces are always on standby, all year round, protecting the UK at home and powerful internationally."
In December, the American forces conducted what it called a "major assault" against Daesh sites in Syria, after an ambush killed two US troops and a civilian interpreter in Palmyra.
The United Nations estimates Daesh still boasts between 5,000 and 7,000 fighters in Syria and Iraq.